Brian Williams, Paula Abdul

Tim McGraw, Shaquille O'Neal, Keri Hilson

Jennifer Connelly, Dr. Oz, Justin Townes Earle

Seth Rogen, Beau Garrett, the Walkmen

Regis Philbin, Hannibal Buress, No Age

Bill Cosby, a Top Ten List presented by Nicole "Snooki" Polizzi, the Black Keys

Vince Vaughn, Mike Wolfe & Frank Fritz, Cage the Elephant

Kevin James, Olivia Munn, The Low Anthem

Kelsey Grammer, Amar'e Stoudemire, Gregg Allman

Joan Rivers, Jeff Caldwell, Wintersleep

Jack Hanna, Steven Tyler

Betty White, Kim & Kourtney Kardashian, the Script

Martin Short, Greta Gerwig, Darius Rucker

Kaley Cuoco, Piers Morgan, Wanda Jackson, Miss Arkansas, Alyse Eady

Nathan Lane, Mike Palascak, Esperanza Spalding

Justin Bieber, Pauley Perrette, Best Coast

Matthew Perry, Chris Elliott, Top Ten with Mitt Romney, the National

Kate Walsh, Jim Gaffigan, Boxer Rebellion

Howard Stern, Naughty By Nature

Martha Stewart, Top Ten with Justin Bieber, Robert Plant

Super Bowl MVP Aaron Rodgers, Martin Lawrence, Steel Magnolia

Adam Sandler, Chris Colfer, Gang of Four

Anderson Cooper, Elton John

Nicole "Snooki" Polizzi, Judah Friedlander, Bryan Ferry

Ed Helms, Ted Alexandro, Steel Magnolia

S.I. Swimsuit Cover Reveal & Top 10, Tom Brokaw, Theophilus London

Forest Whitaker, S.I. Swimsuit Cover Model Irina, Josh Groban, Top Ten with Joy Philbin

Bill Hader, Grocery Bagging Champ Krystal, Amos Lee

Paris Hilton, Nathan Fillion, Scissor Sisters

David Spade, Andy Kindler, Lukas Nelson and Promise of the Real

Donald Rumsfeld, Cobie Smulders

Amy Poehler, Jean Chu and Dusty the Cat, Deerhunter

Rainn Wilson, Hank Aaron

Senator Rand Paul, Bright Eyes

Matthew Morrison, Jeff Altman, Jessica Lea Mayfield

Brian Williams, Trey Parker & Matt Stone, Zac Brown Band

Amanda Seyfried, B.J. Novak

Donald Trump, Vanessa Hudgens, Oh Land

Robin Williams, Judy Greer

Charles Barkley, Sarah Vowell, Cold War Kids

Bradley Cooper, Mindy Kaling, Bob Geldof

Steve Martin, Selena Gomez

Dana Carvey, Dr. Michio Kaku, British Sea Power

Katie Couric, The Pains of Being Pure at Heart

Ben Stiller, Dario Franchitti, The Strokes

"Jungle" Jack Hanna, Danny McBride

Regis Philbin, Snoop Dogg

Norm Macdonald, CC Sabathia, Willie Nelson, Norah Jones and Wynton Marsalis

Chris Rock, Ellen Page, Funeral Party

James Franco, Royal Bangs

Jennifer Garner, Jamie Oliver, Robbie Robertson

Don Rickles, Eva Longoria

Alec Baldwin, Wiz Khalifa

Ricky Gervais, Top Ten with Katie Holmes, Foo Fighters

Courteney Cox, Aziz Ansari, Alison Krauss & Union Station featuring Jerry Douglas

Seth Meyers, Carmelo Anthony, TV on the Radio

Tina Fey, Tommy Johnagin, The Gaslight Anthem

Bill Maher, Cote de Pablo, Lupe Fiasco

Will Ferrell, The Twilight Singers

Kate Hudson, Rich Eisen, Emmylou Harris

Dr. Phil McGraw, Chris Hemsworth, Broadway musical "Catch Me If You Can"

John Krasinski, Brian Kiley, Steve Earle

Brian Williams, Rex Ryan

Caroline Kennedy, Ty Burrell

Betty White, Rick Harrison, Morning Teleportation

Jodie Foster, Tom Dreesen, Neon Trees

Bill Murray, ''The Human Fuse'' Brian Miser, Brother

Albert Brooks, Kristen Wiig

Mark Harmon, Chris Morgan, Hugo

Stupid human tricks, Jim Parsons, Manchester Orchestra

Joan Rivers, Nick Griffin, Okkervil River

Julianna Margulies, Andy Cohen, a Top Ten List presented by Christina Aguilera, White Lies

Martin Short, Melissa McCarthy, Tinie Tempah

Keith Olbermann, Julie Bowen, Ben Harper

Kelly Ripa, Jennifer Lawrence, How to Succeed in Business Without Really Trying

Tracy Morgan, Jake Johannsen, The Airborne Toxic Event

Lady Gaga, Eric Stonestreet, The Vaccines

Ewan McGregor, Scott Pelley, Brad Paisley

Piedmont Bird Callers, Kevin Bacon, Augustana

Ray Romano, Reese Waters, Arctic Monkeys

Meredith Vieira, Indianapolis 500 winner Dan Wheldon, Drum Solo Week kicks off with Anton Fig

Kyle Chandler, Kathy Griffin, Sheila E.

Jon Cryer, Rachel Maddow, Roy Haynes

Neil Patrick Harris, Mike Birbiglia, Neil Peart

Adm. Michael Mullen, Top Ten by Betty White, Black Joe Lewis & the Honeybears

Ryan Reynolds, chef Eric Ripert and the cast of the Broadway musical Anything Goes

Jim Carrey, Rosie Huntington-Whiteley, Todd Rundgren

Samuel L. Jackson, Texas Ranger Josh Hamilton, Jennifer Hudson

Cameron Diaz, Eddie Vedder

Jason Bateman, Amy Sedaris, Top Ten by Keith Olbermann, Drive-By Truckers

Kevin James, pet fashion designer Ada Nieves, Beady Eye

Jason Segel, horse whisperer Buck Brannaman, Noah and the Whale

Shia LaBeouf, Bert Kreischer, Dawes

Tom Hanks, Sleepy Man Banjo Boys

Patrick Dempsey, Erica Hill, Marty Stuart

Julia Roberts, Cake

Emma Watson, George Lopez, Incubus

Roseanne Barr, Tom Felton, Blake Shelton

Ryan Gosling, Gomez

Kyra Sedgwick, Tim Harmston, Nikki Jean

Season 18

Episode 149

Talk

Comedy

Late Show with David Letterman

Season 1

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Season 16

Season 17

Season 19

Season 20

Season 21

Season 22

David Letterman uses mature humor to appeal to his audience in this weeknight series, which gets its music from a house band led by Paul Shaffer. Among the show's most-famous segments are the Top Ten List and Stupid Pet Tricks, the latter of which subsequently led to an additional recurring segment called Stupid Human Tricks.