Nicolas Cage, Anna Torv, Terrence Howard

Dr. Phil McGraw, Tilda Swinton, Tricky

Robin Williams, Shannen Doherty, Duffy

John Malkovich, Hayden Panettiere, Steve Earle

Keira Knightley, Thomas L. Friedman

Jada Pinkett Smith, Chris Russo, Michael Buble

Sen. Barack Obama, LeBron James

Jessica Simpson, Jack Hanna

Meg Ryan, Ricky Gervais

Bill Clinton, Chris Rock

Julianne Moore, Tom Dreesen & Tim Reid, Kings of Leon

Keith Olbermann, Chandra Wilson, Delta Goodrem

Paris Hilton, Usain Bolt, Morningwood

Lance Armstrong, Kristen Wiig, TV on the Radio

Julia Louis-Dreyfus, Michael Cera, Pete Seeger

Anne Hathaway, Josette Sheeran, The Virgins

Kate Walsh, Barry Sonnenfeld, Darius Rucker

Calista Flockhart, Bill Hader, Lucinda Williams

Brian Williams, Tim Robbins

Russell Crowe, Sarah Vowell, The Pretenders

Debra Messing, John Carter, Tegan & Sara

Dennis Quaid, Sarah Chalke, Buddy Guy

Bill Murray, Beck

Jeremy Piven, Elizabeth Banks, Lou Reed

Sarah Silverman, the Teutuls, Ra Ra Riot

Josh Brolin, Amy Sedaris, Blues Traveler

Martin Short, Marv Albert

Sen. John McCain, Ne-Yo

Tina Fey, Frank Caliendo, Tim Montana

Bill O'Reilly, Lauren Conrad

Regis Philbin, James Taylor

Alec Baldwin, Paul Mooney, Ryan Adams

Ashley Olsen, Paul Rudd, John Legend

Marcia Cross, Alan Zweibel

Paris Hilton, Elvis Costello, Jenny Lewis, a Top Ten List by Ricky Gervais

Tom Brokaw, Vera Farmiga

Ben Stiller, Q-Tip

Natalie Portman, Artie Lange, Brad Paisley

Ted Turner, Jamie Oliver, Taylor Swift

Don Rickles, Amy Brenneman, Alicia Keys

Russell Brand, Charlie Haden

Bruce Willis, Sia

Bill Cosby, Matt Braunger

Emma Thompson, Michelle Felicetta, Purple Reign

Carla Bruni Sarkozy, Jack Hanna, Cold Hard Cash

Katie Couric, Dev Patel, Mr. Brownstone

Stephen Colbert, Kristen Stewart, Super Diamond

James Franco, Bruce McCall, The Allstarz

Nicole Kidman, Simon Baker, Kanye West

Reese Witherspoon, Harry Connick Jr.

Teri Hatcher, Ludacris

Denis Leary, John Mayer

Tom Arnold, Faith Hill

Jennifer Connelly, Anderson Cooper, The Duke Spirit

Amy Adams, Michael Sheen, Jamey Johnson

Keanu Reeves, Paula Abdul, Loudon Wainwright III

Sen. John McCain, Bon Iver

Meryl Streep, Jeff Altman

Adam Sandler

Tom Cruise, Fall Out Boy

Jennifer Aniston, Broken Social Scene

Will Smith, Of Montreal

Jerry Seinfeld, Leona Lewis

Dustin Hoffman, Todd Rundgren

Jay Thomas, Mickey Rourke, Darlene Love

Tracy Morgan, Matt Braunger

Kate Hudson, Glasvegas

Kevin James, Becky Quick, Erin McCarley

Ricky Gervais, Rose Byrne, Okkervil River

Kate Winslet, Marv Albert

Kiefer Sutherland, Wendy Liebman

Billy Crystal, Kara DioGuardi

Salma Hayek, Jimmie Walker

Clint Eastwood, Randy Rogers Band

Kyra Sedgwick, Gwen Ifill

Zach Braff, Arj Barker, The Airborne Toxic Event

Brian Williams, Ben Kweller

Evangeline Lilly, Seth Meyers, Andrew Bird

Lauren Graham, Guy Fieri, MENEW

Renee Zellweger, Tony Dungy, Graham Nash sits in with the band

Mary Hicks, the Gaslight Anthem

Ben Roethlisberger, Steve Martin

Rod Blagojevich, Richard Jenkins

Joe Torre, Demetri Martin, Lyle Lovett and John Hiatt

Isla Fisher, extreme fisherman Matt Watson, Mark Olson and Gary Louris, a Top Ten List presented by Lil' Wayne

Dakota Fanning, Keith Alberstadt, Beirut

Naomi Watts, Danny McBride, 2009 Sports Illustrated Swimsuit Issue cover reveal

The crew of US Airways "Miracle On The Hudson" Flight 1549, Heartless Bastards

Joaquin Phoenix, Bar Refaeli, Anthony Hamilton

Chris Russo, the Jonas Brothers, Ashford & Simpson

Martha Stewart, Jake Johannsen, Matt Nathanson

Ellen Pompeo, Daytona 500 winner Matt Kenseth, Willie Nelson with Asleep at the Wheel

Bonnie Hunt, M. Ward

Donald Trump, Antony and the Johnsons

David Spade, Jeffrey Sachs, David Sanborn with Sam Moore

Barbara Walters, Mike Birbiglia, Shemekia Copeland

Katie Couric, U2

Felicity Huffman, Artie Lange, U2

Dr. Phil McGraw, U2

Jon Stewart, U2, a Top Ten List featuring 10 Team USA members from the World Baseball Classic

Season 16

Episode 149

Talk

Comedy

Late Show with David Letterman

Season 1

Season 2

Season 3

Season 4

Season 5

Season 6

Season 7

Season 8

Season 9

Season 10

Season 11

Season 12

Season 13

Season 14

Season 15

Season 17

Season 18

Season 19

Season 20

Season 21

Season 22

David Letterman uses mature humor to appeal to his audience in this weeknight series, which gets its music from a house band led by Paul Shaffer. Among the show's most-famous segments are the Top Ten List and Stupid Pet Tricks, the latter of which subsequently led to an additional recurring segment called Stupid Human Tricks.