Kathy Griffin; Chris Pratt; Big Boi

Regis Philbin; Zedd

Tracy Morgan; Marv Albert; Everest

Michael Strahan; Jessica Chastain; Conor Maynard

Brian Williams; Morrissey

Josh Brolin; Kathryn Bigelow; Ray Wylie Hubbard

Michael J. Fox; Lena Dunham

Catherine Zeta-Jones; Allison Williams; Jon Spencer Blues Explosion

Charlie Sheen; Phil Simms; José James

Jennifer Lawrence; Alan Zweibel; A$AP Rocky

Kim & Kourtney Kardashian; Buddy Guy

Jeremy Renner; Jack Hanna

Kevin Bacon; Brian Kiley; The Amazing

Melissa McCarthy; David Morrissey; David Byrne & St. Vincent

Sylvester Stallone; Al Gore

Jason Bateman; Alison Brie; Shovels & Rope

Al Pacino; Macklemore & Ryan Lewis

Kevin Spacey; Nick Griffin; Emeli Sandé

Gov. Chris Christie; Joe Flacco; Cody Ray Slaughter

Eric Stonestreet; Christopher “Mad Dog” Russo; Brandon Bennett; Norman, the Bicycle-Riding Dog

Joel McHale; Amy Sedaris; Justin Shandor

Sally Field; John Harbaugh; Shawn Klush

Pauley Perrette; Jake Johannsen; Ben Portsmouth

Bill O'Reilly; S.I. Swimsuit Models; The Avett Brothers

Bruce Willis; Kate Upton; Little Big Town

Staff Sgt. Clinton Romesha; AnnaSophia Robb; Robert DeLong

Jerry Seinfeld; Dave Grohl & the Sound City Players with Stevie Nicks

Helen Hunt; Jeff Caldwell; The Maccabees

David Spade; Kenny Licklider; Aaron Neville

Michelle Williams; Chris O'Donnell; von Grey

Hugh Jackman; Zosia Mamet; The Americans

Johnny Depp; Bill Carter and The Blame

Luke Wilson; Dan Mintz; Imagine Dragons

Alec Baldwin; Emmylou Harris with Rodney Crowell

Joan Rivers; Jimmie Johnson; Kendrick Lamar

Tina Fey; Jesse Tyler Ferguson; Solange

Michael Bloomberg; Depeche Mode

Steve Carell; Emilia Clarke; Josh Ritter

Jim Carrey; Richard Thompson

Gerard Butler; Elizabeth Cook

Seth Meyers; Demetri Martin; Dropkick Murphys

Selena Gomez; Bob Sarlatte; Killer Mike

Bill Cosby; Mikaela Shiffrin; Garbage

Eva Mendes; Andy Hendrickson; The Airborne Toxic Event

James Franco; Andrew Borracchini; Ed Sheeran

Brian Williams; Pegi Young & The Survivors

Gary Gulman; Wavves

Shia LaBeouf; Jeff Altman; The Band Perry

Regis Philbin; Broadway musical “Rodgers & Hammerstein's Cinderella”

Louis C.K.; Rachel Maddow; The Flaming Lips

Martin Short; Tyler, the Creator

Chelsea Handler; Ross Bennett; Yeah Yeah Yeahs

Lindsay Lohan; Pete Lee; Gary Clark Jr.

Harrison Ford; Rita Wilson; Jake Bugg

Matthew McConaughey; Ryan Lochte; Steve Earle & The Dukes (& Duchess)

Steve Martin; Edie Brickell; Jenna Fischer

Kate Hudson; A.J. Clemente; Selena Gomez

Jim Parsons; Snoop Lion

Jon Hamm; Ricky Jay; The So So Glos

Mindy Kaling; Nada Bakos; Ben Harper with Charlie Musselwhite

Dr. Phil McGraw; Chris O'Dowd; Phoenix

Tobey Maguire; Tom Odell

Paris Hilton; Miriam Tucker; Atlas Genius

Nathan Lane; Joe Matarese; Kacey Musgraves

John Krasinski; Kerry Washington; James Blake

Zooey Deschanel; Jim Gaffigan; Pistol Annies; Todd Rundgren

Michael Strahan; Alyson Hannigan; Natalie Maines

Jack Hanna; Benedict Cumberbatch

Chris Pine; Tom Dreesen; She & Him

Mark Harmon; Amy Schumer; Luke Bryan

Tom Hanks; cast of “Pippin”

Ed Helms; Hoda Kotb; Brad Paisley

Barbara Walters; Jesse Eisenberg; MS MR

Will Arnett; Trevor Noah; Kurt Vile

Will Smith; The National

Jason Bateman; Piedmont bird callers; John Fogerty

Woody Harrelson; Tommy Johnagin; John Fogerty with Dawes

Neil Patrick Harris; Tony Kanaan; Frank Turner

Nathan Fillion; John Oliver; Local Natives

Johnny Galecki; John Mellencamp & Stephen King; Queens of the Stone Age

Vince Vaughn; Andy Kindler; Queens of the Stone Age

Russell Brand; Michael Shannon; Haim

Dana Carvey; Nick Robinson; cast of “Matilda”

Tom Brokaw; Darlene Love

Harry Connick, Jr.; Dylan Moran

Bill O'Reilly; Greta Gerwig; Quadron

Don Rickles; Nick Cannon; Tom Keifer

Jeff Daniels; Ken Jeong; Jim James

John Travolta; Chris DiStefano; Japandroids

Melissa McCarthy; Idris Elba; Dale Watson and His Lone Stars

Channing Tatum; Tim DeChristopher; Fitz and The Tantrums

Jamie Foxx; Patrick Kane; Wale

Johnny Depp; Marc Maron; Dawes

Michael Cera; Martha Stewart; Ra Ra Riot

Adam Sandler; Joseph Arthur

Salma Hayek Pinault; Tony Hale; Houndmouth

Kevin James; Shaun White; Darius Rucker

Bruce Willis; Bud Selig; Valerie Simpson

Bill Maher; Poppy Montgomery; Pokey LaFarge

Brian Williams; Court Yard Hounds

Season 20

Episode 149

Talk

Comedy

Late Show with David Letterman

Season 1

Season 2

Season 3

Season 4

Season 5

Season 6

Season 7

Season 8

Season 9

Season 10

Season 11

Season 12

Season 13

Season 14

Season 15

Season 16

Season 17

Season 18

Season 19

Season 21

Season 22

David Letterman uses mature humor to appeal to his audience in this weeknight series, which gets its music from a house band led by Paul Shaffer. Among the show's most-famous segments are the Top Ten List and Stupid Pet Tricks, the latter of which subsequently led to an additional recurring segment called Stupid Human Tricks.