Jon Cryer, Chris Kentis, Renee Olstead

Dennis Leary, Sam Easterson

Paul Hamm, Josh Hartnett, Nick Cave

Natalie Coughlin, Carla Gugino, Gavin DeGraw

Maureen Dowd, Tom Ryan

Carly Patterson, Jeff Foxworthy, LL Cool J

Farrah Fawcett, The Clarks

John McCain, Tom Russell

Tim Russert, Snow Patrol

Jane Pauley, Greg Giraldo

National Hollerin' Champions, Neve Campbell, Keane

Regis Philbin, Hoobastank

Martin Short, Alan Jackson

Ray Romano, Avril Lavigne

Drew Barrymore, Aron Ralston

John Kerry, Green Day

Dr. Phil, Gary Sinise

Kelly Ripa, Annie Duke, Elvis Costello

Stupid Human Tricks, Rob Lowe, Mos Def

Julianne Moore, Tom Dreesen

Queen Latifah, Jack Hanna

John Goodman, Tom Waits

Joaquin Phoenix, Austin Stevens, Switchfoot

John Travolta, Tim Frisby, Pearl Jam

Richard Gere, Jason Randal

Howard Dean, Franz Ferdinand

Annette Bening, Bill O'Reilly

Jamie Foxx, Davy Rothbart

Donald Trump, Brian Binnie, Minnie Driver

Brooke Shields, Barry Sonnenfeld

Melina Kanakaredes, Paul Teutul Sr. and Paul Teutul Jr., Ben Harper and the Blind Boys of Alabama

Laura Linney, Richard Lewis, The Wallflowers and Jordan Zevon

Jennifer Lopez, Sue Johanson

Billy Crystal, Ralph Nader

Tony Danza, Emma Roberts, Brian Regan

Jimmy Carter, Brandi Chastain, John Mellencamp

Jude Law, Ricky Gervais

Sarah Michelle Gellar, Tony Kanaan, Sparta

Dustin Hoffman, Joss Stone

Amy Sedaris, Tommy Lee

Johnny Damon, Anne Heche, The Donnas

Tom Brokaw, Mischa Barton

Rosie Perez, Steven Wright

Al Franken, Kristin Bell

Tom Hanks, Nelly

Salma Hayek, Sebastian Bourdais, Jimmy Eat World

Pierce Brosnan, Nigella Lawson, Renee Fleming

Matthew Broderick, Rosario Dawson, Los Lonely Boys

Paul Reubens, Evangeline Lilly, Project Bandaloop

Jerry Seinfeld, Jamie Oliver

Nicolas Cage, Jason Alexander, Morrissey

Renee Zellweger, Chris Raxworthy

Howard Stern, Alanis Morissette

Tom Brady, Damien Fahey

Stupid Pet Tricks, Colin Farrell, The Walkmen

Kevin Spacey, Ben Roethlisberger, Streb

Whoopi Goldberg, Jason Bateman, Marilyn Manson

Natalie Portman, John Mayer

Barack Obama, Jessica Biel

Matt Damon, Lance Armstrong

Alec Baldwin, Ken Jennings

Stupid Human Tricks, Noah Wylie, Sum 41

Sharon Reed, Tyra Banks, Lyle Lovett

Bonnie Hunt, Alex Zanardi

Jim Carrey, Ashanti

Cate Blanchett, Craig Ferguson, The Pixies

Adam Sandler, Sharon Ice

Kate Beckinsale, Ciara and Missy Elliot

Jeff Goldblum, Terrell Owens

Bill Murray, Kaki King

Dennis Quaid, Rusty Wallace, Kaki King

Kristin Johnson, Tom Dreesen

Regis Philbin, Jay Thomas, Darlene Love

Hilary Swank, Andy Dick, Green Day

Ethan Hawke, Maria Menounos, Alicia Keys

Kiefer Sutherland, Marv Albert, The Black Keys

Michael Keaton, Jamie Lynn Spears

Kevin Bacon, Caroline Rhea, Wilco

Samuel L. Jackson, Amy Poehler, B.B. King

Randy Johnson, Aisha Tyler, Razorlight

Rudolph Giuliani, Daniel Banks

Marge Helgenberger, Ryan Seacrest, My Chemical Romance

Amy Sedaris, Andy Kindler

Jack Hanna, Teri Polo

Ice Cube, Chris Russo, Interpol

Harvey Fierstein, Regina King, Steven Van Zandt, ... And You Will Know Us By the Trail of Dead

Robert Downey Jr., Nicole Richie

Jerry Lewis, Sophia Bush

Peter Lassally, Doc Severinson

Debra Messing, Peyton Manning

Patricia Heaton, John Witherspoon, Gibson/Baldwin Grammy Jazz Ensembles

Elton John, Eva Mendes

Al Franken, Matthew Fox, Nanci Griffith

Will Smith, Tom Brady

Kevin James, Aishwarya Rai, Three Doors Down

David Hyde Pierce, Howie Day

Billy Crystal, Patrick Lawler

Paris Hilton, Bill Burr

Dr. Phil, Unwritten Law

Kid Scientists, Keanu Reeves, Michael Buble

Season 12

Episode 149

Talk

Comedy

Late Show with David Letterman

Season 1

Season 2

Season 3

Season 4

Season 5

Season 6

Season 7

Season 8

Season 9

Season 10

Season 11

Season 13

Season 14

Season 15

Season 16

Season 17

Season 18

Season 19

Season 20

Season 21

Season 22

David Letterman uses mature humor to appeal to his audience in this weeknight series, which gets its music from a house band led by Paul Shaffer. Among the show's most-famous segments are the Top Ten List and Stupid Pet Tricks, the latter of which subsequently led to an additional recurring segment called Stupid Human Tricks.