Howie Mandel, Dock Diving Dogs, Dirty Projectors

Jeremy Piven, Rumer Willis, Black Crowes

Jason Bateman and White House official Dr. John P. Holdren

Billy Crystal and John Fogerty

Neil Patrick Harris, Steve Mazan, Edward Sharpe & The Magnetic Zeros

Tony Blair and Julianna Margulies

Jay-Z, Martha Stewart, and George Jones

Matt Damon and Jack Hanna

Michael Douglas, Leighton Meester, and Kid Cudi

President Barack Obama

Former President Bill Clinton and LeBron James

Simon Baker and Mary J. Blige

Craig Ferguson, Kristin Chenoweth, and Snow Patrol

Bruce Willis, LL Cool J, and The Noisettes

Felicity Huffman, Dr. Mehmet Oz, and The Avett Brothers

Kelsey Grammer, Alyson Hannigan, and Miranda Lambert

Madonna and Harry Connick Jr.

Woody Harrelson and Kim Kardashian

Larry David, Olivia Wilde and Tom Russell

Steve Martin and Lea Michele

CBS Orchestra bandleader Paul Shaffer, Eliza Dushku and KISS

Vince Vaughn, Carey Mulligan, and Rosanne Cash

Kristin Davis and Barry Sonnenfeld

Jon Hamm, Andy Kindler, and Brett Dennen

Garry Shandling, Kaley Cuoco, and Tim McGraw

Sienna Miller, Aziz Ansari, and Dead By Sunrise

Tina Fey, Chris Russo, and Mika

Don Rickles and Built To Spill

Uma Thurman and Tim McGraw

Charles Barkley, Cheryl Hines, Harper Simon

Courteney Cox, William Knoedelseder, Florence and the Machine

Patrick Dempsey, Bud Selig, Sting

Tom Hanks, Weezer, a Top Ten List presented by Chad Ochocinco

Regis Philbin, Brian Regan, Weezer

Julia Louis-Dreyfus, Guy Fieri, Carrie Underwood, Top Ten with Meb Keflezighi

Al Gore, Brad Paisley, a Top Ten List presented by Michael Bublé

Bill Cosby, Ryan Bingham

Derek Jeter, Jorge Posada & Andy Pettitte, Bill Maher, Keith Urban

Ricky Gervais, Brian Regan, Ralph Stanley and the Clinch Mountain Boys

Bill Murray, Gabourey “Gabby” Sidibe

Jack Hanna, Shakira

Kate Walsh, Norah Jones

Kid Scientists, Amanda Peet, the Cribs with Johnny Marr

Mariah Carey, Kumail Nanjiani

Sharon Stone, Seth Meyers, Wyclef Jean and Cyndi Lauper

Penelope Cruz, Joe Cada, The Script

Robert Pattinson, Ray Davies

Stephen Colbert, Emily Blunt, John Mayer

Viggo Mortensen, Paula Poundstone, and Lyle Lovett

Robin Williams, Ashley Greene

Zac Efron, Carrie Fisher, Rihanna

Natalie Portman, Adam Lambert

Ray Romano, Anna Kendrick

Barbara Walters, Blakroc

Rachel Weisz, Rob Thomas

Kate Hudson, Dr. James Hansen, Tori Amos

Kyra Sedgwick, Brian Scott McFadden, Joe Perry

Hugh Grant, Zoe Saldana, Alicia Keys

Sarah Jessica Parker, Leona Lewis

Robert Downey Jr, Martin Short, and Kris Allen

Shannon Eis, Jude Law, and Matisyahu

Tobey Maguire, Tom Dreesen, and Alicia Keys

Maggie Gyllenhaal and John Witherspoon

Susan Sarandon, Colbie Caillat

Alec Baldwin, Jay Thomas, Darlene Love

Michael Cera, Jenna Elfman, David Gray

Amy Adams, Zachary Levi, Vampire Weekend

Sigourney Weaver, Marv Albert, Julian Casablancas

Bradley Cooper, Rachel Maddow, Nick Jonas

Teri Hatcher, Jake Johannsen, The Dodos

Whoopi Goldberg, Jason Sudeikis, Findlay Brown

Kiefer Sutherland, Keri Russell, The Hotrats

Denzel Washington, Dr. O. Wayne Isom, The Low Anthem

Glenn Close, Eddie Brill, Matt Morris

Kristen Bell, Randy Jackson, The Heavy

Dwayne Johnson, Bettina Luescher, The Swell Season

Claire Danes, Will Arnett, James Taylor, Carole King

Harrison Ford, Lou Reed, Blind Boys of Alabama

Catherine Zeta-Jones, Jeff Stilson, Charlotte Gainsbourg

Bruce Willis, Ne-Yo

John Travolta, Shaun White, Ben Harper & Relentless7

Sarah Silverman, Jeremy Renner, Nneka, a Top Ten List presented by Paris Hilton

Jamie Foxx, Amanda Seyfried, Robin Thicke

Jack Hanna, Joe Wong, the Swell Season

Drew Brees, Sandra Bullock, Josh Turner

Jennifer Garner, the Sports Illustrated swimsuit issue cover model, Sade

Jessica Biel, Christoph Waltz

Regis and Joy Philbin, a Top Ten List presented by Benicio Del Toro

Jeff Bridges, Joe Wong, the Soft Pack

Tracy Morgan, the Daytona 500 winner, Fanfarlo

Ben Kingsley, Mary J. Blige

Ewan McGregor, Abby Elliott, Mumford & Sons

Scarlett Johansson, Daniel Merriweather

Nicole Richie, comic Tom Papa.

Bill Murray, Ludacris

Mitt Romney, Mia Wasikowska

Jerry Seinfeld, Tom Brokaw

Tom Hanks, Spoon

Matt Damon, Danny Bhoy, Corinne Bailey Rae

Kelly Ripa, Lady Antebellum

Season 17

Episode 149

Talk

Comedy

Late Show with David Letterman

Season 1

Season 2

Season 3

Season 4

Season 5

Season 6

Season 7

Season 8

Season 9

Season 10

Season 11

Season 12

Season 13

Season 14

Season 15

Season 16

Season 18

Season 19

Season 20

Season 21

Season 22

David Letterman uses mature humor to appeal to his audience in this weeknight series, which gets its music from a house band led by Paul Shaffer. Among the show's most-famous segments are the Top Ten List and Stupid Pet Tricks, the latter of which subsequently led to an additional recurring segment called Stupid Human Tricks.