Amanda Peet, Tom Dreesen

Jeff Goldblum, George Miller

Drea de Matteo, Sarah Vowell, The Doves

Peter Jennings, John Witherspoon

John McEnroe, Piper Perabo, Queens of the Stone Age

Jennifer Esposito, Marianne Faithful

Bill Clinton, Nanci Griffith

Regis Philbin, Linda Thompson

Megan Mullally, Rich Hall

Bruce Willis, Eve

Jack Hanna, Tom Cavanagh, Civil War Reenactment

Reese Witherspoon, Juan Pablo Montoya, India.Arie

Rose McGowan, Phillipe Petit

Lauren Graham, Colin Quinn

Patricia Heaton, Murray Walker

David Schwimmer, Avril Lavigne

Anthony LaPaglia, Effie Nielson, Clinic

Edward Norton, John Mayer

David Arquette, Todd Lynn

Jennifer Love Hewitt, Tom Petty and The Heartbreakers

John McCain, David Sedaris

Charles Barkley, Franco Zeffirelli, Nitty Gritty Dirt Band

Michelle Pfeiffer, Bon Jovi

Johnny Knoxville, Ron White

Debra Messing, Pink

Thandie Newton, Faith Hill

Rudolph Giuliani, Naomi Watts

Samuel L. Jackson, Santana & Michelle Branch

P. Diddy, Eddie Brill

Bonnie Hunt, Christina Aquilera

Salma Hayek, Tori Amos

Warren Zevon

Jerry Seinfeld, Foo Fighters

Don Rickles, Jim Gaffigan

Stupid Human Tricks, Sean Hayes, Willie Nelson & Ryan Adams

Julianne Moore, Grant Paulsen, Blind Boys of Alabama

Kid Inventors, Tom Brokaw, The Wallflowers

Brittany Murphy, Al Lubel

Robin Williams, Emily Proctor

Kelly Ripa, Emmitt Smith, Missy Elliott

Barbara Walters, Joe Pantoliano

Maggie Gyllenhaal, Pearl Jam

Al Gore, Pearl Jam

Kevin James, matchbox 20

Shania Twain, Cristiano da Matta

Adam Sandler, Pussycat Dolls

Ice Cube, Cast of Hairspray

Harry Connick Jr., Larry Miller

Stupid Pet Tricks, Lisa Kudrow, Audioslave

George Clooney, Jack Hanna

Ray Romano, Jurassic 5

Amy Sedaris, The Strokes

Liza Minnelli, Jann Karam

Jennifer Lopez, Sum 41

Jason Alexander, Ryan Adams

Nia Vardalos, Barry Sonnenfeld

Allison Janney, Martin Scorsese

Natasha Richardson, Mike Birbiglia, David Gray

Catherine Zeta-Jones, Coldplay

Drew Barrymore, Rod Stewart

Denzel Washington, Daniel Bouloud

Tom Hanks, Phish

Liv Tyler, Jay Thomas, Darlene Love

Ashton Kutcher, Jason Kidd

Isabella Rossellini, Mort Sahl

Michael Caine, George Foreman

Richard Gere, Chris Elliott

Merv Griffin, Interpol

Renee Zellweger, Chuck Barris

Andy Richter, Rich Hall

Jimmy Kimmel, Simon Baker

Claire Danes, Bob Sarlatte

Sandra Bullock, Marv Albert

George Clooney, Soundtrack of Our Lives

Joan Rivers, Kathleen Edwards

Simon Cowell, Topher Grace, Vienna Teng

Regis Philbin, John C. Reilly

Tina Fey, Jonathan Ames, Johnny Marr & The Healers

Ellen DeGeneres, Zwan

Bonnie Hunt, John Witherspoon

Show #1944Kate Hudson, Jack Hanna

Matthew McConaughey, John Gruden, The Roots

Kelsey Grammer, Michael Tong, B.B. King and Shemeika Copeland

Stupid Pet Tricks, Tom Brokaw, The Pretenders

Brendan Fraser, Kids in The Hall, Bonnie Raitt, Keb' Mo, Kim Wilson

Matthew Broderick, Tony Bennett & k.d. Lang

Amy Brennamen, Nate Erwin, Vince Gill

Queen Latifah, Colin Quinn, Lou Reed

Kid Scientists, Kurt Russell

Kate Winslet, Dennis Regan, Rufus Wainwright

Dr. Phil, Beck

Vince Vaughn, Sarah Vowel, Beck

Kevin Spacey, Reggie Miller

Champion Turkey Callers, Marg Helgenberger, The Flaming Lips

Jeff Daniels, Lynne Cox, Steven Wright

Steve Martin, Foo Fighters

Stupid Human Tricks, Sharon Osborne, Norah Jones

Bruce Willis, Dan Rather, Carmen Electra, Brian Kiley

John McEnroe, Tom Arnold, Eric Ripert, Todd Barry, Jason Mras

Regis Philbin, Charles Grodin, Susan Lucci, Greg Giraldo, Kathleen Edwards

Season 10

Episode 149

Talk

Comedy

Late Show with David Letterman

Season 1

Season 2

Season 3

Season 4

Season 5

Season 6

Season 7

Season 8

Season 9

Season 11

Season 12

Season 13

Season 14

Season 15

Season 16

Season 17

Season 18

Season 19

Season 20

Season 21

Season 22

David Letterman uses mature humor to appeal to his audience in this weeknight series, which gets its music from a house band led by Paul Shaffer. Among the show's most-famous segments are the Top Ten List and Stupid Pet Tricks, the latter of which subsequently led to an additional recurring segment called Stupid Human Tricks.