Andy Kindler, motocross demo with Travis Pastrana, Baby Gramps

Zach Braff, Jeff Brendenburg, The Roots

Snoop Dogg, Charlie Hill, OK Go

Julianne Moore, radio-show hosts Opie and Anthony

Al Franken, Todd Snider

Maria Sharapova, Martha Stewart, Justin Timberlake

Ashton Kutcher, Sam Hornish, Jr., TV on the Radio

Dwayne "The Rock" Johnson, Norm MacDonald

Anne Heche, Luke Ravenstahl, The Who

Johnny Knoxville, Rachael Ray

Dr. Phil McGraw, Willie Tyler and Lester, Sekou Bunch

Patrick Dempsey, Jay Johnson and Darwin, Kasabian

Marg Helgenberger, Ronn Lucas and Scorch, Diana Krall

Ted Turner, Jeff Dunham and Walter, Fergie

LeBron James, Todd Oliver and Irving, Ludacris

Ray Liotta, Elvis Costello & Tony Bennett, Billy Garcia

Billy Bob Thornton, Lily Capehart, Sean Lennon

Amanda Peet, Nigella Lawson, Bob Seger

Sir Richard Branson, Dane Cook, Monica

Nathan Lane, Jeff Caldwell

Pete Rose, Roy Wood Jr., Cecilia Mansilla

Andy Dick, Keith Olbermann, Brazilian Girls

Alec Baldwin, Vladae the Dog Wizard, Jerry Lee Lewis & Neil Young

Frank Caliendo, Rachael Harris, Xzibit, Phil Pfister

Amy Sedaris, Trey Anastasio

Robin Williams, J.P. Calderon, Sam Moore with Wynonna

Nicky Hilton, Bob Woodward, Joseph Arthur

Jon Stewart, Nick Lachey

Katie Couric, Brian Kiley, Alan Jackson

Diddy, Neil Patrick Harris

Tom Arnold, Brian Regan, the latest "Survivor: Cook Islands" castaway

Tina Fey, Mike Golic & Mike Greenberg, The Killers

Julia Louis-Dreyfus, Jay Thomas, John Legend

Tim Robbins, Gene Rurka, Russell Thompkins Jr. and The New Stylistics

Bill O'Reilly, Jeff Altman, Tilly and the Wall

Borat, Tiki Barber, Beck

Rachel Weisz, David Rakoff, Morningwood

Gary Sinise, Joanne Carson, Jim Norton

Rosie O'Donnell, Lady Sovereign

Martin Short, Kinky Friedman

Will Ferrell, Jack Hanna

Dustin Hoffman, Jamie Oliver, The Metropolitan Opera

Kiefer Sutherland, Jenna Fischer, Rocco DeLuca

Daniel Craig, documentary film subject Teri Horton, Elvis Costello, Rosanne Cash

Robin Williams, Rich Little, George Jones

Jack Black & Kyle Gass, Fred Travalena, Tenacious D

Ellen DeGeneres, Gordie Brown, +44

Christopher Guest, Frank Caliendo, The Game

Sen. John Edwards, Kevin Pollak, Will Arnett

Jerry Seinfeld, Dan Patrick

Hugh Jackman, Chris Elliott, Jimmie Johnson

Matthew Broderick, Lupe Fiasco & Jill Scott

Eugene Levy, John Mayer

Helen Hunt, DJ Shadow, Q-Tip and Lateef

Kate Winslet, Tom Waits

George Clooney, The Decemberists

Richard Simmons, Kate Walsh, Ciara

Jennifer Connelly, Tom Dreesen, Shiny Toy Guns

Danny DeVito, 16-year-old duct tape expert William Beacom, Silversun Pickups

Matt Damon, Barbara Walters

Howard Stern, Gwen Stefani

Kid Scientists, Regis Philbin, Robert Randolph

Will Smith, Evanescence

Clint Eastwood, Matthew Fox

Frank Caliendo as John Madden, Ben Stiller, Rodrigo & Gabriela

Beyonce, Marv Albert, The Dears

Renée Zellweger, holiday toy demonstration, Taking Back Sunday

Tom Brokaw, Cold War Kids

Cate Blanchett, Jay Thomas, Darlene Love

Martin Short, Donal Logue

Matt Lauer, Artie Lange, Augustana

Cedric the Entertainer, Wesley Autrey, Switchfoot

Donald Trump, Mary Lynn Rajskub

David Arquette, Jennifer Hudson

Penelope Cruz, Gary Mule Deer, Ben E. King

Peter O'Toole, Marc Maron

Julianne Moore, Madonna, The Hold Steady

Kristin Chenoweth, John Witherspoon, Josh Ritter

Amy Sedaris, Jason Randal, America with Ryan Adams & Ben Kweller

Paul Newman, Sebastian Bourdais, Diana Ross

Tina Fey, Terri and Bindi Irwin

Harry Shearer, Vera Farmiga, Mat Kearney

Dan Rather, Tricia Helfer, Andy Kindler

Kevin Spacey, Alicia Keys, Nellie McKay & The Brooklyn Philharmonic

Ricky Gervais, Forest Whitaker, The Shins

Frank Caliendo, Mandy Moore, Rosanne Cash

Bill Murray, LeBron James

David Spade, Alexandra Pelosi, Dustin Kensrue

Dr. Phil McGraw, Fall Out Boy

Randy Jackson, Harry Connick Jr., Regis

Chris Elliott, Kelly Ripa, John Mellencamp

Jack Hanna, Katherine Heigl, Patty Griffin

Rachael Ray, Frank Caliendo, The Fab Faux

Drew Barrymore, Rickie Lee Jones, Kevin Johnson with Clyde & Matilda

Peyton Manning, Dan Horn with Orson, The Cat Empire

Martha Stewart, Otto Petersen with George, Norah Jones

Sienna Miller, NAS, Jim Barber with Seville

Tracy Morgan, Gabrielle Union, Brad Cummings and Rex

Jim Carrey, Daytona 500 winner Kevin Harvick

Barbara Walters, David Neeleman, K-os

Season 14

Episode 149

Talk

Comedy

Late Show with David Letterman

Season 1

Season 2

Season 3

Season 4

Season 5

Season 6

Season 7

Season 8

Season 9

Season 10

Season 11

Season 12

Season 13

Season 15

Season 16

Season 17

Season 18

Season 19

Season 20

Season 21

Season 22

David Letterman uses mature humor to appeal to his audience in this weeknight series, which gets its music from a house band led by Paul Shaffer. Among the show's most-famous segments are the Top Ten List and Stupid Pet Tricks, the latter of which subsequently led to an additional recurring segment called Stupid Human Tricks.