William Shatner; Chelsea Handler; Newton Faulkner

Liv Tyler; Judd Apatow; Usher

Jeff Foxworthy; Arianna Huffington; N.E.R.D.

Dustin Hoffman; Gordon Ramsay; Flobots

Will Smith; Pete Sampras; Ed Harcourt

Russell Brand; Bill Engvall; Aimee Mann

Justin Timberlake; Karen Allen; Sheryl Crow

Dana Carvey; Spencer Breslin; Priscilla Ahn

Mike Myers; Abigail Breslin; David Cook

Larry the Cable Guy; Bob Costas; Ashanti

Anne Hathaway; Gabriel Iglesias; Amos Lee

Don Rickles; Charles Barkley, Kenny Smith, Ernie Johnson; Jewel

The Rock; Tom Papa; Against Me!

Wanda Sykes; James McAvoy; Duffy

Bette Midler; Al Roker; Bette Midler

Selma Blair; Kevin Nealon; Steve Tyrell

Aaron Eckhart;  Los Lonely Boys; Dara Torres

Sara Bareilles; Jarod Miller

Adam Carolla; Kathy Griffin; Wynton Marsalis; Willie Nelson

Elizabeth Banks; Michael Caine

Will Ferrell; Mary McCormack; James Hunter

David Duchovny; Reese Hoffa; Jakob Dylan

John C. Reilly; Venus Williams; Gavin Rossdale

David Spade; Jordana Spiro; Coldplay

Tim Allen; Demi Lovato; One Republic

Kyra Sedgewick; Chris Matthews; Alanis Morissette

Gillian Anderson; Dave Attell; The Duke Spirit

Kevin Costner; D.L. Hughley; The Time

Kelsey Grammer; Hugh Rowland; Drew Sherwood; Gavin Degraw

Kevin Spacey; Triumph the Insult Comic Dog; Jesse McCarthy

Julie Scardina; Brendan Fraser; Gnarls Barkley

Seth Rogen; Joan Allen; Third Day

Rainn Wilson; Emeril Lagasse; Sergio Mendes Ft. Ledisi

Rosie Perez; Robin Thicke

Bill Cosby; Emma Stone

Ben Stiller; the Jonas Brothers

Robert Downey Jr.; Anna Faris; Toby Keith

Jack Black; Conor Oberst

Nick Nolte; Solomon Burke

Scarlett Johansson; Luke Ford; Chris Cornell

John McCain; Dara Torres; Juliana Hatfield

Norm MacDonald; Gordon Ramsay; B.B. King

Bill Maher; Low vs Diamond

Josh Brolin, Chelsea Handler, The Killers

Heidi Klum, Robert Pattinson, Seal

Debra Messing, Cody Willard, Celine Dion

Kathy Griffin, David Frost, Colbie Caillat

Michael Phelps, JB Smoove

Brian Williams, Kirk Fox, Common

Cate Blanchett, Tim Reid & Tom Dreesen, Taylor Swift

Will Smith, Paula Deen, k.d. lang

Kate Beckinsale, Sean "Diddy" Combs, Sara Bareilles & Ingrid Michaelson

Wanda Sykes, Michael Phelps, Lyle Lovett

Jamie Foxx, David Gregory

Kate Winslet, Dame Edna, Sheryl Crow

Jim Carrey, Rosario Dawson, Relient K

Charlize Theron; Matt Lucas & David Walliams

Adam Sandler, Zooey Deschanel, Los Lonely Boys

James Franco, Doris Kearns Goodwin, Melissa Etheridge

Owen Wilson, Julie Scardina, Natalie Cole

Terry Bradshaw, Jack Witherspoon, Iron & Wine

Queen Latifah, Adam Carolla, Pussycat Dolls

Anne Hathaway, Brady Barr, Jeff Dunham

Dustin Hoffman, Mary Lynn Rajskub, Lady GaGa

Daniel Craig, Taraji P. Henson, Eagles of Death Metal

David Duchovny, Richard Roeper, The All-American Rejects

Mickey Rourke, Toni Collette, John Legend

Cherie Blair, Ralph Fiennes, Brett Dennen

Kevin James, Emma Roberts, MuteMath

Hugh Laurie, Chuck Todd, Band From TV

Jimmy Fallon, Neil DeGrasse Tyson, Lee Ann Womack

Wanda Sykes, Bernice Gallego, Buckcherry

Howie Mandel, Jerome Bettis, Lady Antebellum

Marisa Tomei, Dr. Grey Stafford, Ty Barnett

Michelle Obama; Chris Rock; Darius Rucker

Rainn Wilson, Nikki Glaser, Hoobastank

Dakota Fanning, Bradley Cooper, the Neville Brothers

Jenna Fischer, Justin Long, Franz Ferdinand

Elizabeth Banks, Dev Patel, James Morrison

Kate Winslet, Danny Boyle, Akon

Penelope Cruz, D.L. Hughley, Sara Bareilles

Drew Barrymore, Serena Williams, will.i.am

Jennifer Aniston, Santonio Holmes, Jamey Johnson

Dave Salmoni, Frank Langella, Ben Lee

Simon Baker, Heidi Montag and Spencer Pratt, Duffy

Bill Maher, Viola Davis, Raphael Saadiz

Anderson Cooper; Steve Byrne; Sarah McLachlan

Miley Cyrus; Jason Statham; David Cook

Kiefer Sutherland; Lisa Lampanelli; Barry Manilow

Larry the Cable Guy, Chris Matthews, Adele

Bill Maher, Kristin Chenoweth, Nickelback

Hugh Jackman, Tenacious D

Jay Mohr, Marjorie Johnson, Scott Weiland

Ron Howard, Jonas Brothers

Larry the Cable Guy, Malin Akerman, the Fray

Bob Newhart, Rachel Maddow, Bettye Lavette

Russell Brand, Neko Case

Jarrod Miller, Sienna Miller, Tom Jones

Christina Ricci, Papa Roach

Elisabeth Hasselbeck, Demetri Martin, Rocco De Luca & The Burden

Season 17

President George W. Bush & Laura Bush, Ben Harper with Charlie Musselwhite

Talk

Comedy

The Tonight Show with Jay Leno

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Season 18

Season 19

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Season 21

Specials

Jay Leno hosts some of the biggest celebrities in the world.