Howie Mandel, Amanda Bynes, Emmylou Harris

Jamie Foxx, Tim Gunn, Paolo Nutini

Dane Cook, Ali Larter, LCD Soundsystem

Jessica Alba, D.L. Hughley, Cold War Kids

Hugh Laurie, Sherri Shepherd, The Editors

Dwayne "The Rock" Johnson, Dennis Kucinich, Diana Krall

Jennifer Love Hewitt, Jeff Corwin, Reba McEntire with Vince Gill

Steve Carell, Madison Pettis, Bright Eyes

Ben Stiller, Tony Snow, Raul Midon

Teri Hatcher, Kevin McKidd, Queen Latifah

Patricia Heaton, Emeril Lagasse, Tori Amos

Tom Selleck, Carlos Mencia, Bobbie and Willie Nelson

John Larroquette, Chelsea Handler, Matchbox Twenty

Cate Blanchett, Tyler Perry, Annie Lennox

Ben Affleck, Jim Norton, The Shins

Jaime Pressly, Brady Barr, Blue Man Group

Dana Carvey, Malin Akerman, Plain White T's

Joaquin Phoenix, Gordon Ramsay, Vanessa Carlton

Christina Applegate, Bill O'Reilly, Alicia Keys

James Spader, Lara Logan, Steve Byrne

Reese Witherspoon, David Koechner, PJ Harvey

Sen. Barack Obama, Orny Adams, Keith Urban

Jerry Seinfeld, Amy Ryan, Evanescence

Halle Berry, Greg Grunberg, Dwight Yoakam

Russell Crowe, Jenna Bush, Carrie Underwood

Tom Cruise, Rep. Ron Paul, Sex Pistols

Eva Mendes, Marjorie Johnson, Barry Manilow

Denzel Washington, Dave Salmoni, LeAnn Rimes

Steve Carell, Manny Ramirez, Backstreet Boys

Gov. Mike Huckabee, Emeril Lagasse, Chingy

Howie Mandel, Jason Lewis, Joe Nichols

Animals With Jarod Miller, John Caparulo, Blake Lewis

Ron Paul, Christopher Titus, Shakira

Pamela Anderson, Mary J. Blige

Jules Sylvester and animals, Maria Bartiromo, Finger Eleven

Jimmy Kimmel, Elon Gold, OneRepublic

Arsenio Hall, Melanie Metz & Peggy Willenberg, Seether

Marilu Henner, Brady Barr, Jordan Sparks

Bill Maher, Carrie Ann Inaba & Bruno Tonioli, Taylor Swift

Chris Matthews, John Roy, Jill Scott

D.L. Hughley, Joe Ligotti, Sara Bareilles

Mitt Romney, Ryan Sheckler, Jonas Brothers

Simon Cowell & Ryan Seacrest, Tavis Smiley, Shaggy

David Gregory, Performing Birds, Puddle Of Mudd

Adam Carolla, Richard Roeper, Shooter Jennings

Animals With Julie Scardina, Chelsea Handler, Buckcherry

Hulk Hogan, Mad Scientist David Willey, Natasha Bedingfield

Chazz Palminteri, Alison Sweeney, Dierks Bentley

Lester Holt, Blue Ribbon Baker Marjorie Johnson, Raheem DeVaughn

Animals with Dave Salmoni, Tom Green, Maroon 5

Sen. John McCain, Rudy Giuliani, Shelby Lynne

Tom Brokaw, Terrell Owens, Graham Colton

Dan Rather, Mike Rowe, Josh Kelley

Insects with Brent Karner, Stephen Baldwin, J. Holiday

Frank Caliendo, Chimp Rescuer Eugene Cussons, Flo Rida

Arsenio Hall, Paula Deen, James Blunt

Brian Williams, Ahmed Ahmed, Enrique Iglesias

Larry the Cable Guy, Bobby Knight, Andrea Bocelli

Larry the Cable Guy, Bruno Tonioli, Glen Hansard & Markéta Irglová

Joan Embery and Animals, Larry the Cable Guy, Mika

Russell Crowe, Larry the Cable Guy, Willie Nelson

Kristen Chenoweth, Russell Peters, Lifehouse

Reese Witherspoon, Alex Cambert, Gary Allan

Will Ferrell, Hayden Christensen, The Hives

Garth Brooks, Christina Ricci

Heidi Klum, James McAvoy, John Fogerty

Colin Farrell, Bill O'Reilly, Herbie Hancock

Eric Bana, Catherine O'Hara, Tift Merritt

Dennis Quaid, David Koechner, Lupe Fiasco

Billy Ray Cyrus, Miley Cyrus, Brooke Shields

Wanda Sykes, Bryan Cranston, Cat Power

Dave Salmoni and Animals, Patricia Arquette, The Punch Brothers

Dominic Monaghan, Ethan Bortnick, Sheryl Crow

America Ferrera, Bob Saget, The Blind Boys of Alabama

Bill Cosby, Novak Djokovic, Landon Pigg

Howie Mandel, Minnie Driver

Gordon Ramsay

Kate Beckinsale, Carlos Mencia, The Bravery

Terry Bradshaw, James Carville & Mary Matalin, Michael McDonald

Ryan Phillippe, Lisa Lampanelli, Jim Lauderdale

John Edwards, Leslie Mann, Nada Surf

Adam Carolla, Geraldo Rivera, The Black Crowes

Peter O'Toole, Katt Williams, Leona Lewis

Abigail Breslin, Seth Meyers, Steve Earle

John Krasinski, Joe Torre, José González

Conan O'Brien, Anderson Cooper, Allison Moorer

John Larroquette, Kid Inventors, k.d. lang

Jodie Foster, Cedric the Entertainer, Lili Haydn

Mike Huckabee; Emeril Lagasse; Chingy

Steve Carell, Kathie Lee Gifford, Ani DiFranco

Sen. Hillary Clinton, Patton Oswalt, Ferras

David Spade, Nora Hardwick, Ben Lee

Pamela Anderson; Mary J. Blige

Jules Sylvester; Maria Bartiromo; Finger Eleven

Jimmy Kimme; Elon Gold; OneRepublic

Keanu Reeves, Chelsea Handler, The Redwalls

William Shatner, Tricia Helfer, Ryan Bingham

Mark Harmon, Corbin Maxey, Ray J

Brad Garret; Ingrid Michaelson; John Melendez

Charles Barkley, The Young@Heart Chorus

Season 16

President George W. Bush & Laura Bush, Ben Harper with Charlie Musselwhite

Talk

Comedy

The Tonight Show with Jay Leno

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Specials

Jay Leno hosts some of the biggest celebrities in the world.